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Ashkenazi genetics link high IQ and disease

by chanan tigay, jta

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new york | A reported link between Ashkenazi intelligence genes and susceptibility to genetic disorders is clearly mixed news for the descendants of Eastern European Jews.

It may come as little surprise, then, that reactions to a new study linking the two are a mixed bag as well.

After all, if what the University of Utah researchers say is true, some Jewish mothers may just have had their dreams for brilliant children turned to nightmares.

Beyond that, it may also mean that Ashkenazim have, albeit unwillingly, "been part of an accidental experiment in eugenics," as The Economist magazine put it in a recent article.

"It has brought them some advantages. But, like the deliberate eugenics experiments of the 20th century, it also has exacted a terrible price."

The mere mention of eugenics — which refers to a movement to improve humankind by controlling genetic factors through mating — is enough to ring bells that many Jews would rather not hear 60 years after the Allied defeat of the Nazis.

According to the study, slated to appear in an upcoming issue of the Journal of Biosocial Science, Ashkenazim do better than average on IQ tests, scoring some 12-15 points above the test's mean value. But they also are more likely than any other ethnic groups to suffer from diseases such as Tay-Sachs, Gaucher's disease and Niemann-Pick — related conditions that can be debilitating and deadly.

The new study hypothesizes that the genetic disorders could be the side effects of genes that facilitate intelligence.

In some of the Ashkenazi disorders, individuals experience extra growth and branching of connectors linking their nerve cells. Too much of this growth may lead to disease; increased but limited growth, though, could breed heightened intelligence.

But for some people, ascribing collective traits to entire ethnic groups — especially to European Jews — reminds them that the Nazis heaped a pile of supposed genetic characteristics on that continent's Jews and used the characteristics as a basis to exterminate them.

Indeed, the researchers say they had difficulty finding a journal that would publish their findings.

For other people, criticizing such research on this basis reeks of political correctness. This is real science, they say, with real potential to help save Jewish — and other — lives.

"When you study genetics in order to cure diseases, that's great," said James Young, a Jewish studies professor at the University of Massachusetts at Amherst.

"But when genetics are studied as a way to characterize or essentialize a whole ethnic group or nation of people, then I think it's very problematic."

As to concerns about what it means to say that one group of people is genetically smarter than others, Henry Harpending, a professor of anthropology at the University of Utah and one of the study's three authors, said that such complaints boil down to political correctness.

"It's no secret," he said of the Ashkenazi IQ numbers. "Your grandmother told you this."

Indeed, the study notes that although Ashkenazi Jews made up just 3 percent of the U.S. population during the last century, they won 27 percent of the country's Nobel Prizes in science and account for more than half of the world's chess champions.

But could this research actually end up helping anybody? Gregory Cochran, one of the study's authors, hopes so.

"I don't have the cure to any disease in my pocket. I wish I did," he said. But "if this all pans out, you learn something about how the brain works. Who knows? Maybe you can do something to help some people one day."

The study says that because European Jews in medieval times were restricted to jobs in finance, money lending and long-distance trade — occupations that required greater mental gymnastics than fields such as farming, dominated by non-Jews — their codes over the course of some generations selected genes for enhanced intellectual ability.

This process allowed these Jews to thrive in the limited scope of professions they were allowed to pursue. Further, in contrast to today, those who attained financial success in that period often tended to have more children than those who were less financially stable, and those children tended to live longer.

It is for this reason, the researchers said, that many Ashkenazi Jews today have high IQs — and it may also be the reason they suffer from the slew of genetic diseases.

According to the researchers, many individuals carrying the gene for one of these diseases also receive an "IQ boost."


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